CAS No.50-24-8 Prednisolone

Prednisolone

Identification
Name Prednisolone
CAS Registry Number 50-24-8
Synonyms DEHYDROHYDROCORTISONE;HYDRODELTALONE;METACORT AND RALONE;METACORTANDROLONE;11B,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE;11BETA,17ALPHA,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE;11BETA 17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE;11-BETA,17-ALPHA,21-HYDROXY-1,4-PREGNADIENE-3,20-DIONE
Molecular Structure Prednisolone   50-24-8
Molecular Formula C21H28O5
Molecular Weight 240 ℃ (dec.)(lit.)
Hazard Codes: Details
Risk Statements: 22-34-11
Safety Statements: 22-45-36/37/39-26-16

CAS 50-24-8 Wiki / 50-24-8 MSDS

Prednisolone
Prednisolone-2D-skeletal.svg
Prednisolone-3D-balls.png
Clinical data
Trade names many
Synonyms 11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a] phenanthren-3-one
AHFS/Drugs.com Monograph
MedlinePlus a682794
License data
  • US FDA: prednisolone
Pregnancy
category
  • AU: A
  • US: C (Risk not ruled out)
ATC code
  • A07EA01 (WHO) C05AA04 (WHO), D07AA03 (WHO), H02AB06 (WHO), R01AD02 (WHO), S01BA04 (WHO), S02BA03 (WHO), S03BA02 (WHO)
Legal status
Legal status
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Biological half-life 2–3 hours
Excretion urine
Identifiers
CAS Number
  • 50-24-8 YesY
PubChem CID
  • 5755
IUPHAR/BPS
  • 2866
DrugBank
  • DB00860 YesY
ChemSpider
  • 5552 YesY
UNII
  • 9PHQ9Y1OLM
KEGG
  • D00472 YesY
ChEBI
  • CHEBI:8378 YesY
ChEMBL
  • CHEMBL131 YesY
ECHA InfoCard 100.000.020
Chemical and physical data
Formula C21H28O5
Molar mass 360.444 g/mol
3D model (JSmol)
  • Interactive image
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Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers.[1][2] Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma, and multiple sclerosis.[2] It is used by mouth, injection into a vein, as a skin cream, and as eye drops.[3]

Side effects with short term use include nausea and feeling tired.[1] More severe side effects include psychiatric problems, which may occur in about 5% of people.[4] Common side effects with long term use include bone loss, weakness, yeast infections, and easy bruising.[2] While short term use in the later part of pregnancy is safe, use long term or early in early pregnancy is occasionally associated with harm to the baby.[5] It is a glucocorticoid made from hydrocortisone (cortisol).[6]

Prednisolone was discovered and approved for medical use in 1955.[6] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[7] It is available as a generic medication.[2] The wholesale cost in the developing world is about 0.01 to 0.02 USD per day.[8]